The synthesis and the characterization of three new naproxen decorated polymers are described. A versatile and general approach is employed to link the drug to polymers, affording the derivatives with a very high degree of purity. The release of the drug from the conjugates proved to be exceptionally slow, even in acidic aqueous media, and the kinetic of the process seems to be triggered by their solubility in water. On the other hand, the interesting outcome of the first ex vivo drug release experiments on human blood samples makes this preliminary study valuable for future investigations on the use of these polymeric prodrugs in in vivo treatment of inflammatory states.
Characterization of naproxen–polymer conjugates for drug-delivery / Forte, Gianpiero; Chiarotto, Isabella; Giannicchi, Ilaria; Loreto, Maria Antonietta; Martinelli, Andrea; Micci, Roberta; Pepi, Federico; Rossi, Serena; Salvitti, Chiara; Stringaro, Annarita; Tortora, Luca; VECCHIO CIPRIOTI, Stefano; Feroci, Marta. - In: JOURNAL OF BIOMATERIALS SCIENCE POLYMER EDITION. - ISSN 0920-5063. - STAMPA. - 27:1(2016), pp. 69-85. [10.1080/09205063.2015.1108637]
Characterization of naproxen–polymer conjugates for drug-delivery
FORTE, GIANPIERO;CHIAROTTO, Isabella;GIANNICCHI, ILARIA;LORETO, Maria Antonietta;MARTINELLI, Andrea;PEPI, Federico;SALVITTI, CHIARA;VECCHIO CIPRIOTI, Stefano;FEROCI, Marta
2016
Abstract
The synthesis and the characterization of three new naproxen decorated polymers are described. A versatile and general approach is employed to link the drug to polymers, affording the derivatives with a very high degree of purity. The release of the drug from the conjugates proved to be exceptionally slow, even in acidic aqueous media, and the kinetic of the process seems to be triggered by their solubility in water. On the other hand, the interesting outcome of the first ex vivo drug release experiments on human blood samples makes this preliminary study valuable for future investigations on the use of these polymeric prodrugs in in vivo treatment of inflammatory states.File | Dimensione | Formato | |
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1-2016Characterization of naproxen–polymer conjugates for drug-delivery.pdf
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